Opportunity Information: Apply for W81XWH 22 LRP IPA
The Department of Defense Lupus Research Program (LRP) Impact Award (Funding Opportunity Number W81XWH-22-LRP-IPA, CFDA 12.420) is designed to fund lupus research projects that aim for major, field-shifting advances rather than modest, incremental progress. The program is intentionally broad in scope and welcomes the full range of scientific and clinical lupus research ideas, as long as the proposed work tackles a lupus issue that truly matters and could meaningfully change what researchers and clinicians understand or can do if the project succeeds. A central expectation is that the application presents a clearly defined, testable hypothesis supported by strong scientific reasoning, typically built from careful analysis of existing literature and logical inference. Preliminary data is not required but is encouraged when available, especially if it strengthens feasibility or supports the rationale.
A defining feature of this opportunity is its emphasis on impact and significance for people living with lupus. Applicants are expected to spell out, in plain and explicit terms, why the problem is important, what would change if the research works, and how that change would matter to lupus patients, clinical practice, or the direction of lupus science. The Impact Award is positioned as a high-risk, high-reward mechanism: it is willing to support ambitious ideas, including novel experimental strategies, provided the underlying rationale is convincing and the approach reflects a deep understanding of lupus biology, heterogeneity, and clinical complexity. By contrast, studies that mainly extend previously published findings in small steps are discouraged and may be viewed as insufficiently impactful.
From a technical and review standpoint, the Research Strategy must demonstrate both thoughtful scientific logic and a rigorous plan for execution. The program expects experimental methods that are either genuinely innovative or strongly justified by critical evaluation of prior work. Alongside the concept, the Research Team is also a key review element: the investigators and collaborators should collectively have the expertise, track record, and capabilities needed to complete the proposed work successfully, particularly given the ambitious nature of “impact” projects. Another non-negotiable requirement is alignment with at least one of the FY22 LRP Focus Areas, meaning the project must clearly fit within the specific priority areas identified for that fiscal year.
Funding is provided through assistance agreements, which can be issued as either a grant or a cooperative agreement. The deciding factor is how much involvement the DoD anticipates during the project. If the agency expects no substantial involvement, the award is typically a grant (consistent with 31 USC 6304). If substantial involvement is expected, the mechanism becomes a cooperative agreement (31 USC 6305), and the award documentation will describe the nature of that involvement, which can include collaboration, participation, or intervention in aspects of the research. The final mechanism and the official project start date are determined during award negotiations rather than being fixed upfront.
Budget-wise, the anticipated maximum total costs for the entire period of performance for an FY22 LRP Impact Award are capped at $750,000. Programmatically, the CDMRP planned to allocate about $5.25 million total to fund roughly seven awards, although actual funding depends on federal fund availability, the number of submissions, and how applications score during scientific and programmatic review. The original application closing date listed for this opportunity was September 1, 2022, and awards were expected to be made no later than September 30, 2023, with FY22 funds anticipated to expire for use on September 30, 2023. Eligibility is broadly described as unrestricted, meaning it is open to many types of applicant organizations, subject to any additional eligibility clarifications contained in the full announcement text.Apply for W81XWH 22 LRP IPA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Lupus, Impact Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on May 17, 2022.
- Applicants must submit their applications by Sep 01, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: DoD Lupus Research Program (LRP) Impact Award (W81XWH-22-LRP-IPA)
What is the DoD Lupus Research Program (LRP) Impact Award?
The Department of Defense (DoD) Lupus Research Program (LRP) Impact Award is a funding opportunity intended to support lupus research projects that pursue major, field-shifting advances. The program is aimed at research that could meaningfully change what scientists and clinicians understand about lupus or what they can do in practice if the project succeeds.
What is the funding opportunity number and CFDA listing for this award?
The Funding Opportunity Number is W81XWH-22-LRP-IPA and the CFDA number is 12.420.
What kind of research does the Impact Award prioritize?
The award prioritizes ambitious lupus research with the potential for high impact, rather than modest or incremental extensions of existing work. The scope is intentionally broad and may include scientific and clinical research, as long as the project addresses a lupus issue that truly matters and could lead to meaningful change if successful.
Is the program limited to specific lupus topics or research approaches?
The program is described as intentionally broad in scope and welcomes a full range of scientific and clinical lupus research ideas. However, the project must align with at least one of the FY22 LRP Focus Areas, meaning it must clearly fit within the specific priority areas identified for that fiscal year.
Is alignment with FY22 LRP Focus Areas required?
Yes. Alignment with at least one FY22 LRP Focus Area is described as a non-negotiable requirement, and the application must clearly demonstrate that fit.
What does the program mean by "impact"?
Impact is centered on significance for people living with lupus and on whether the work could shift the field. Applicants are expected to explain clearly why the problem matters, what would change if the research works, and how that change would affect lupus patients, clinical practice, or the overall direction of lupus research.
Does the Impact Award support high-risk, high-reward research?
Yes. The Impact Award is positioned as a high-risk, high-reward mechanism. It is willing to support ambitious ideas and novel experimental strategies, provided the rationale is convincing and the approach reflects a strong understanding of lupus biology, heterogeneity, and clinical complexity.
Are incremental studies discouraged?
Yes. Studies that mainly extend previously published findings in small steps are discouraged and may be viewed as insufficiently impactful.
Do applicants need to include a hypothesis?
Yes. A central expectation is that the application presents a clearly defined, testable hypothesis supported by strong scientific reasoning, typically built from careful analysis of existing literature and logical inference.
Is preliminary data required for the application?
No. Preliminary data is not required, but it is encouraged when available, especially if it strengthens feasibility or supports the scientific rationale.
What are reviewers likely looking for in the Research Strategy?
The Research Strategy is expected to demonstrate thoughtful scientific logic and a rigorous plan for execution. The program expects methods that are either genuinely innovative or strongly justified through critical evaluation of prior work.
How important is the research team to this award?
The Research Team is a key review element. Investigators and collaborators are expected to collectively demonstrate the expertise, track record, and capabilities needed to successfully carry out the proposed work, especially given the ambitious nature of “impact” projects.
What funding mechanism is used for this opportunity?
Funding is provided through assistance agreements, which may be issued either as a grant or as a cooperative agreement.
What determines whether an award is a grant or a cooperative agreement?
The deciding factor is how much involvement the DoD anticipates during the project. If the agency expects no substantial involvement, the award is typically a grant (consistent with 31 USC 6304). If substantial involvement is expected, the mechanism becomes a cooperative agreement (31 USC 6305), and the award documentation will describe the nature of that involvement.
What kinds of DoD involvement might occur under a cooperative agreement?
When a cooperative agreement is used, the DoD involvement can include collaboration, participation, or intervention in aspects of the research, as described in the award documentation.
When is the final award mechanism decided?
The final mechanism (grant vs. cooperative agreement) is determined during award negotiations rather than being fixed upfront.
When is the official project start date set?
The official project start date is determined during award negotiations.
What is the maximum budget allowed under the FY22 LRP Impact Award?
The anticipated maximum total costs for the entire period of performance are capped at $750,000.
How much total funding was the program planning to allocate, and how many awards were anticipated?
The CDMRP planned to allocate about $5.25 million in total funding to support roughly seven awards, although actual funding depends on federal fund availability, the number of submissions received, and how applications score during scientific and programmatic review.
Are the number of awards and total funds guaranteed?
No. The planned totals are contingent on factors such as federal fund availability, the volume of submissions, and outcomes of scientific and programmatic review.
What was the original application closing date for this opportunity?
The original application closing date listed was September 1, 2022.
By when were awards expected to be made?
Awards were expected to be made no later than September 30, 2023.
When were FY22 funds anticipated to expire for use?
FY22 funds were anticipated to expire for use on September 30, 2023.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is open to many types of applicant organizations, subject to any additional eligibility clarifications contained in the full announcement text.
What is the main message applicants should communicate about patient relevance?
Applicants are expected to state plainly why the problem is important and how success would matter to people living with lupus, influence clinical practice, or redirect lupus research in a meaningful way.
Browse more opportunities from the same category: Science and Technology and other Research and Development
Next opportunity: Upgrading and Improving the Use of Feed Ration Formulation Software in Cambodia, Laos and Nigeria
Previous opportunity: Technical and Vocational Education and Training (TVET) Activity
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for W81XWH 22 LRP IPA
Applicants also applied for:
Applicants who have applied for this opportunity (W81XWH 22 LRP IPA) also looked into and applied for these:
| Funding Opportunity |
|---|
| DoD Lupus, Idea Award Apply for W81XWH 22 LRP IA Funding Number: W81XWH 22 LRP IA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Lupus, Transformative Vision Award Apply for W81XWH 22 LRP TVA Funding Number: W81XWH 22 LRP TVA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Fiscal Year (FY) 2023 DoD Research and Education Program for Historically Black Colleges and Universities and Minority-Serving Institutions (HBCU/MI) Apply for W911NF 22 S 0010 Funding Number: W911NF 22 S 0010 Agency: Department of Defense, Dept of the Army -- Materiel Command Category: Science and Technology and other Research and Development Funding Amount: $800,000 |
| Global Innovation through Science and Technology (GIST) Initiative for the South Caucasus Apply for SFOP0008972 Funding Number: SFOP0008972 Agency: Department of State, Bureau of Oceans - Int. Environmental - Scientific Category: Science and Technology and other Research and Development Funding Amount: $395,000 |
| Computer and Information Science and Engineering (CISE) Research Initiation Initiative Apply for 22 598 Funding Number: 22 598 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: $175,000 |
| Geometric Analysis Apply for PD 22 1265 Funding Number: PD 22 1265 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Military Burn, Clinical Translational Research Award Apply for W81XWH 22 MBRP CTRA Funding Number: W81XWH 22 MBRP CTRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Military Burn, Technology/Therapeutic Development Award Apply for W81XWH 22 MBRP TTDA Funding Number: W81XWH 22 MBRP TTDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Centers for Homeland Security - Extension of Period of Performance Apply for DHS 22 ST 061 COE EXT001 Funding Number: DHS 22 ST 061 COE EXT001 Agency: Department of Homeland Security, Office of Procurement Operations - Grants Division Category: Science and Technology and other Research and Development Funding Amount: $9,200,000 |
| Harmful Algal Bloom Field Validation Program: Aquatic Nuisance Species, Broad Agency Announcement Special Topic Area. Apply for W81EWF 22 HAB BAA Funding Number: W81EWF 22 HAB BAA Agency: Department of Defense, Dept. of the Army -- Corps of Engineers Category: Science and Technology and other Research and Development Funding Amount: $4,000,000 |
| DOD Chronic Pain Management, Investigator-Initiated Research Award Apply for W81XWH 22 CPMRP IIRA Funding Number: W81XWH 22 CPMRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Chronic Pain Management, Translational Research Award Apply for W81XWH 22 CPMRP TRA Funding Number: W81XWH 22 CPMRP TRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Chronic Pain Management, Clinical Exploration Award Apply for W81XWH 22 CPMRP CEA Funding Number: W81XWH 22 CPMRP CEA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Breast Cancer, Transformative Breast Cancer Consortium Award Apply for W81XWH 22 BCRP TBCCA 2 Funding Number: W81XWH 22 BCRP TBCCA 2 Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Reaching a New Energy Sciences Workforce for High Energy Physics (RENEW-HEP) Apply for DE FOA 0002759 Funding Number: DE FOA 0002759 Agency: Department of Energy - Office of Science, Office of Science Category: Science and Technology and other Research and Development Funding Amount: $500,000 |
| DOD Parkinson's Synergistic Idea Award Apply for W81XWH 22 PRP SIA Funding Number: W81XWH 22 PRP SIA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Parkinson's Investigator-Initiated Research Award Apply for W81XWH 22 PRP IIRA Funding Number: W81XWH 22 PRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Parkinson's Early Investigator Research Award Apply for W81XWH 22 PRP EIRA Funding Number: W81XWH 22 PRP EIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Joint DMS/NIGMS Initiative to Support Research at the Interface of the Biological and Mathematical Sciences Apply for 22 600 Funding Number: 22 600 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: $1,200,000 |
| “Delivering Scalable Harmful Algal Bloom (HAB) Prevention and Management Technologies for Freshwater Ecosystems for the Ohio River” Apply for W81EWF 22 SOI 0021 Funding Number: W81EWF 22 SOI 0021 Agency: Department of Defense, Dept. of the Army -- Corps of Engineers Category: Science and Technology and other Research and Development Funding Amount: $500,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "W81XWH 22 LRP IPA", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.