Opportunity Information: Apply for PAR 23 295
The Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional) opportunity (PAR 23 295) is a National Institutes of Health (NIH) discretionary grant designed to support small, focused research projects that examine how advances in human genetics and genomics affect people, institutions, and society. The core aim is to fund studies that dig into the ethical questions, legal challenges, and social consequences that arise as genetic and genomic technologies evolve and become more widely used in research, healthcare, public health, and other settings. Projects can be tightly scoped and are well suited to a single investigator or a small team, especially when the work is exploratory, theory-building, or intended to clarify an emerging issue that needs careful analysis before larger-scale research is launched.
The NOFO emphasizes flexibility in approach. Applicants may propose studies using single methods (for example, qualitative interviews, legal research, surveys, policy analysis, or economic modeling) or mixed methods that combine more than one approach. NIH also encourages meaningful involvement of key stakeholders when it makes sense for the research question. In practical terms, that could include patients, research participants, clinicians, genetic counselors, community organizations, Tribal partners, policy makers, industry representatives, IRB members, or others directly affected by genomic practices and policies. Stakeholder engagement is positioned as a way to keep the research grounded in real-world needs and to ensure the questions being asked reflect on-the-ground concerns, not just academic debates.
A major area of interest for this opportunity is normative or conceptual work. That includes focused legal, economic, philosophical, anthropological, or historical analyses, particularly when they address new or fast-developing issues in genetics and genomics. This is important because some ELSI problems are not primarily about collecting large datasets; they are about clarifying values, identifying conflicts between existing rules and new technologies, testing the logic of policy arguments, or mapping the social dynamics that shape how genomics is used and understood. The NOFO also explicitly supports projects that collect preliminary data (often used to justify and refine a later, larger application) and projects that conduct secondary analyses of existing data, which can be a cost-effective way to generate insights without building a new data collection effort from scratch.
On eligibility, this announcement is intentionally broad and open to many types of organizations. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations other than small businesses; and small businesses. In addition, the NOFO highlights several other eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; Indian/Native American Tribal Governments other than federally recognized entities; and non-domestic (non-U.S.) entities, meaning foreign organizations can apply as well.
From an administrative standpoint, the funding instrument is a grant, and the opportunity is categorized under multiple NIH-related assistance listings (CFDA numbers 93.113, 93.121, 93.172, 93.173, 93.242, 93.279, 93.310, 93.313, 93.399, 93.855, 93.865, 93.989), reflecting that ELSI work can intersect with many NIH institutes and mission areas. The award ceiling listed is $50,000. The posted original closing date is 2026-11-16, and the opportunity record indicates a creation date of 2023-10-30.
Overall, the program is best read as support for targeted, high-value ELSI studies that can be completed on a small budget and that produce clear conceptual, practical, or policy-relevant outcomes. Strong applications are likely to be those that identify a concrete genomics-related ELSI problem, explain why it is timely or emerging, use an appropriate and credible method (or set of methods), and show how the findings could inform future research, governance, clinical practice, community decision-making, or public understanding of genetics and genomics.Apply for PAR 23 295
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.242, 93.279, 93.310, 93.313, 93.399, 93.855, 93.865, 93.989.
- This funding opportunity was created on 2023-10-30.
- Applicants must submit their applications by 2026-11-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| BRAIN Initiative: Marmoset Colonies for Neuroscience Research (U24 Clinical Trials Not Allowed) Apply for RFA MH 25 115 Funding Number: RFA MH 25 115 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Marmoset Coordination Center (U24 Clinical Trials Not Allowed) Apply for RFA MH 25 116 Funding Number: RFA MH 25 116 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Blueprint and BRAIN Initiative Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award (F99/K00 Clinical Trial Not Allowed) Apply for RFA NS 24 030 Funding Number: RFA NS 24 030 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required) Apply for PA 24 186 Funding Number: PA 24 186 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 Independent Basic Experimental Studies with Humans Required) Apply for PA 24 192 Funding Number: PA 24 192 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required) Apply for PA 24 181 Funding Number: PA 24 181 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required) Apply for PA 24 183 Funding Number: PA 24 183 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 Independent Basic Experimental Studies with Humans Required) Apply for PA 24 177 Funding Number: PA 24 177 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required) Apply for PA 24 195 Funding Number: PA 24 195 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Not Allowed) Apply for PAR 24 133 Funding Number: PAR 24 133 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) Apply for PA 24 248 Funding Number: PA 24 248 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Basic Experimental Studies with Humans Required (BESH)) Apply for PAR 24 227 Funding Number: PAR 24 227 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Human Brain Single-cell Genomics Explorer (U24 - Clinical Trial Not Allowed) Apply for RFA NS 24 038 Funding Number: RFA NS 24 038 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $1,000,000 |
| Environmental Health Disparities Centers (P50) Clinical Trial Optional Apply for RFA MD 24 010 Funding Number: RFA MD 24 010 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed) Apply for PAR 25 233 Funding Number: PAR 25 233 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R21 Clinical Trial Optional) Apply for PAR 25 143 Funding Number: PAR 25 143 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 25 168 Funding Number: PA 25 168 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed) Apply for PAR 25 298 Funding Number: PAR 25 298 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $375,000 |
| NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Apply for PA 25 302 Funding Number: PA 25 302 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: $50,000 |
| NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) Apply for PA 25 304 Funding Number: PA 25 304 Agency: National Institutes of Health Category: Education, Environment, Health, Income Security and Social Services Funding Amount: Case Dependent |
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