Opportunity Information: Apply for PAR 16 411

The NCI Outstanding Investigator Award (R35), listed under FOA number PAR-16-411, is a discretionary National Institutes of Health grant program run by the National Cancer Institute that supports cancer research in any scientific area related to cancer. The central idea is to provide stable, longer-term funding to highly accomplished investigators who already have strong track records of productivity and impact in cancer research, and who are proposing an exceptional research program. Rather than pushing investigators to stay tightly within conservative, short-term aims, this award is specifically meant to create room for bolder scientific choices, including higher-risk questions, more adventurous shifts in research direction, and the time needed to develop or refine new tools, methods, or techniques that could open up new lines of discovery.

A defining feature of the R35 Outstanding Investigator Award is its emphasis on the investigator and overall research vision, not just a narrow project plan. It is designed for established Program Directors/Principal Investigators (PDs/PIs) who are nominated by their institutions, reflecting that the institution is expected to put forward candidates it considers outstanding and well-positioned to benefit from flexible, long-horizon support. In practice, this structure aims to reduce the constant cycle of shorter grant renewals and allow investigators to devote more energy to science itself, while also encouraging creative approaches that may not fit easily into traditional, highly prescriptive project formats.

Eligibility is broad across many types of U.S.-based applicant organizations. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where applicable); for-profit organizations other than small businesses; and small businesses. The FOA also highlights a range of mission- or community-focused institution types that may apply, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it draws a clear boundary around non-U.S. applicants: non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply directly, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed when they meet the NIH definition in the NIH Grants Policy Statement, meaning a U.S.-based applicant can include certain foreign elements of the research when justified and compliant with NIH policy.

From an administrative standpoint, the opportunity is categorized under the broad funding activity areas of education and health, and it is associated with multiple CFDA numbers (93.393 through 93.399), reflecting NCI programs across several cancer-related assistance listings. The documented award ceiling is $600,000 (as provided in the source information), and the original closing date shown is January 7, 2017, with a creation date of August 17, 2016. Overall, the program is positioned as a high-impact mechanism for backing proven cancer researchers with the freedom and runway needed to pursue ambitious work, especially work that might be too uncertain, too exploratory, or too method-development-heavy to compete well under more conventional, narrowly scoped grant mechanisms.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NCI Outstanding Investigator Award (R35)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.397, 93.398, 93.399.
  • This funding opportunity was created on 2016-08-17.
  • Applicants must submit their applications by 2017-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $600,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for PAR 16 411

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NCI Small Grants Program for Cancer Research (NCI Omnibus R03) Apply for PAR 16 416

Funding Number: PAR 16 416
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Funding Number: RFA LM 17 002
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"High" or "Medium" Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (R21) Apply for PA 16 425

Funding Number: PA 16 425
Agency: National Institutes of Health
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"High" or "Medium" Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (R01) Apply for PA 16 426

Funding Number: PA 16 426
Agency: National Institutes of Health
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Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24) Apply for RFA DA 17 019

Funding Number: RFA DA 17 019
Agency: National Institutes of Health
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Grand Opportunity in Medications Development for Substance-Use Disorders (U01) Apply for PAR 16 431

Funding Number: PAR 16 431
Agency: National Institutes of Health
Category: Education, Health
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Strategic Alliances for Medications Development to Treat Substance Use Disorders (R01) Apply for PAR 16 430

Funding Number: PAR 16 430
Agency: National Institutes of Health
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Health Promotion Among Racial and Ethnic Minority Males (R21) Apply for PA 16 432

Funding Number: PA 16 432
Agency: National Institutes of Health
Category: Education, Health
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Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R01) Apply for PA 16 427

Funding Number: PA 16 427
Agency: National Institutes of Health
Category: Education, Health
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Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R21) Apply for PA 16 429

Funding Number: PA 16 429
Agency: National Institutes of Health
Category: Education, Health
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Encouraging Appropriate Care Using Behavioral Economics through Electronic Health Records (R21/R33) Apply for RFA AG 17 013

Funding Number: RFA AG 17 013
Agency: National Institutes of Health
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Drug Abuse Dissertation Research (R36) Apply for PA 16 443

Funding Number: PA 16 443
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Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R34) Apply for RFA MH 17 361

Funding Number: RFA MH 17 361
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Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R01) Apply for RFA MH 17 360

Funding Number: RFA MH 17 360
Agency: National Institutes of Health
Category: Education, Health
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Multi-Site Pilot and Feasibility Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R34) Apply for PAR 16 456

Funding Number: PAR 16 456
Agency: National Institutes of Health
Category: Education, Health
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Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01) Apply for PAR 16 455

Funding Number: PAR 16 455
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