Opportunity Information: Apply for RFA DK 25 024
The NIH, through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), is offering an R01 grant opportunity called "Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)" under funding opportunity number RFA-DK-25-024 (CFDA 93.847). The overall goal is to fund multidisciplinary research teams that bring together complementary expertise in HIV research and in the biology and disease processes most relevant to NIDDK. In practice, this means projects should focus on organs, tissues, and biological systems tied to NIDDKs mission areas, such as metabolism, endocrine function, digestive diseases, liver and gastrointestinal biology, nutrition-related pathways, and kidney/urologic systems, while directly addressing how HIV contributes to related health problems.
The NOFO is centered on mechanism-focused science. NIDDK is looking for teams that will comprehensively interrogate fundamental biological mechanisms driving HIV-associated comorbidities, co-infections, and complications that fall within NIDDK priorities. Rather than mainly supporting descriptive or purely epidemiologic work, the emphasis is on understanding pathobiology and pathophysiology: how HIV infection (and potentially its treatment, chronic inflammation, immune activation, viral reservoirs, or metabolic changes) leads to downstream dysfunction in specific tissues and systems. The intent is that this mechanistic understanding will help move the field toward strategies that prevent, mitigate, or relieve HIV-associated complications that intersect with diabetes, digestive diseases, kidney disease, and related metabolic or physiological disorders.
The "TEAMS" framing signals that applications are expected to be genuinely collaborative and multidisciplinary, not just a single-lab project with minor outside input. Competitive proposals will typically feature investigators with distinct but integrated expertise, for example combining HIV virology or immunology with renal physiology, hepatology, gut mucosal biology, endocrinology, metabolism, nutrition science, or systems biology. The expectation is that the team approach will allow deeper, more complete interrogation of mechanisms than a single-discipline effort, and that the project plan will show clear integration across disciplines with a coherent strategy for generating actionable biological insight.
This is an R01 mechanism, and clinical trials are optional, meaning applicants may propose either non-clinical trial research or a study that includes a clinical trial component, as long as it is justified by the mechanistic aims and aligns with NIDDK mission interests. The opportunity is categorized as discretionary grant funding within the broad activity category of food and nutrition and health, reflecting NIDDKs program scope and the NIH context of the announcement.
A wide range of applicants are eligible. Standard domestic governmental and academic entities may apply, including state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; and private institutions of higher education. Also eligible are federally recognized tribal governments, public housing authorities/Indian housing authorities, and tribal organizations that are not federally recognized. The NOFO also welcomes nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), and small businesses. In addition, NIDDK explicitly identifies other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving institutions, historically Black colleges and universities, tribally controlled colleges and universities, faith-based and community-based organizations, eligible federal agencies, U.S. territories or possessions, and even non-U.S. entities (foreign organizations) and regional organizations, which underscores an interest in broad participation and in assembling the best possible teams for the scientific questions being targeted.
Key administrative details included in the listing are an original closing date of November 21, 2024, and an award ceiling of $500,000. The source entry also notes the posting/creation date as August 7, 2024. While the number of expected awards is not specified in the provided text, the ceiling provides a sense of the scale NIDDK anticipates for individual projects.
In short, this NOFO funds team-based, mechanistic HIV pathogenesis research that squarely targets HIV-related complications in NIDDK-relevant organs and systems, with the explicit aim of generating biological insight that can ultimately inform prevention or alleviation of HIV-associated comorbidities, co-infections, and complications tied to metabolism, digestive health, and kidney-related disease areas.Apply for RFA DK 25 024
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2024-08-07.
- Applicants must submit their applications by 2024-11-21. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH funding opportunity from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for an R01 grant titled "Toward ElucidAting MechanismS of HIV Pathogenesis within the Mission of the NIDDK (Pathogenesis TEAMS) (R01 Clinical Trial Optional)." The funding opportunity number is RFA-DK-25-024 and the CFDA number listed is 93.847.
What is the overall goal of the Pathogenesis TEAMS R01?
The goal is to support multidisciplinary research teams that combine HIV expertise with expertise in NIDDK-relevant biology and disease processes, in order to uncover fundamental mechanisms of HIV pathogenesis as it relates to HIV-associated comorbidities, co-infections, and complications in NIDDK mission areas.
Which NIH Institute is sponsoring this opportunity?
The opportunity is sponsored by the NIH through NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases).
What does "Pathogenesis TEAMS" mean in practical terms?
"TEAMS" indicates that applications are expected to be genuinely collaborative and multidisciplinary. Projects should be designed around integrated contributions from investigators with complementary expertise, rather than a single-lab project with minimal external input.
What type of science is most emphasized in this NOFO?
The NOFO emphasizes mechanism-focused science. NIDDK is looking for projects that comprehensively interrogate fundamental biological mechanisms (pathobiology/pathophysiology) that drive HIV-associated comorbidities, co-infections, and complications within NIDDK priorities.
Are descriptive or purely epidemiologic studies a good fit?
Based on the description provided, the emphasis is not on mainly descriptive or purely epidemiologic work. The priority is understanding mechanisms: how HIV infection and related processes lead to downstream dysfunction in specific tissues and systems relevant to NIDDK.
What kinds of HIV-related factors may be studied under this opportunity?
The opportunity highlights mechanistic work related to HIV infection and potentially its treatment, chronic inflammation, immune activation, viral reservoirs, and metabolic changes, insofar as these factors contribute to dysfunction in NIDDK-relevant organs, tissues, and biological systems.
What NIDDK mission areas are considered relevant for proposed projects?
Projects should focus on organs, tissues, and biological systems tied to NIDDK mission areas, such as metabolism, endocrine function, digestive diseases, liver and gastrointestinal biology, nutrition-related pathways, and kidney/urologic systems, while directly addressing how HIV contributes to related health problems.
What kinds of health outcomes or complications is NIDDK aiming to address?
The focus is on HIV-associated comorbidities, co-infections, and complications that intersect with diabetes, digestive diseases, kidney disease, and related metabolic or physiological disorders, with the intent of generating insight that can inform prevention, mitigation, or relief of these complications.
What grant mechanism is being used?
This opportunity uses the NIH R01 mechanism.
Are clinical trials allowed under this R01?
Yes. The announcement is labeled "Clinical Trial Optional," meaning applicants may propose either non-clinical trial research or a study that includes a clinical trial component, as long as it is justified by the mechanistic aims and aligns with NIDDK mission interests.
What would make a clinical trial component appropriate here?
A clinical trial component would need to be justified by the mechanistic aims and be aligned with NIDDK mission interests (for example, mechanistic interrogation of HIV-related complications in NIDDK-relevant systems).
What types of expertise are expected on a competitive team?
Competitive proposals will typically feature distinct but integrated expertise. Examples given include combining HIV virology or immunology with disciplines such as renal physiology, hepatology, gut mucosal biology, endocrinology, metabolism, nutrition science, or systems biology.
Is this intended to support single-investigator projects?
The description indicates that applications are expected to be team-based and multidisciplinary, with clear integration across disciplines. A single-lab project with only minor outside input would generally not reflect the "TEAMS" framing described.
What should applicants demonstrate about collaboration and integration?
Applicants should present a coherent strategy showing how the team approach enables deeper mechanistic interrogation than a single-discipline effort, and how the disciplines are integrated to generate actionable biological insight.
What funding category is this opportunity associated with?
The opportunity is categorized as discretionary grant funding within the broad activity category of food and nutrition and health, reflecting the NIDDK program scope and NIH context of the announcement.
Who is eligible to apply?
A wide range of applicants are eligible, including domestic governmental and academic entities (such as state, county, city/township, special district governments, independent school districts, public/state-controlled institutions of higher education, and private institutions of higher education). Additional eligible applicants include federally recognized tribal governments, public housing authorities/Indian housing authorities, and tribal organizations that are not federally recognized.
Are nonprofits eligible?
Yes. The NOFO welcomes nonprofit organizations, including both 501(c)(3) and non-501(c)(3) nonprofits.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also listed as eligible in the provided information.
Are small businesses eligible?
Yes, small businesses are explicitly included in the eligible applicant types provided.
Are minority-serving institutions specifically identified as eligible?
Yes. The eligible applicant list explicitly includes Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving institutions, historically Black colleges and universities (HBCUs), and tribally controlled colleges and universities.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed among the eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the eligible applicant types provided.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicants.
Are foreign (non-U.S.) organizations eligible?
Yes. The provided information explicitly notes that non-U.S. entities (foreign organizations) and regional organizations are eligible, underscoring broad participation.
What is the application deadline listed for this opportunity?
The listing states an original closing date of November 21, 2024.
What is the award ceiling?
The listing notes an award ceiling of $500,000.
Is the number of expected awards provided?
No. The provided text states that the number of expected awards is not specified.
When was this opportunity posted/created?
The source entry notes a posting/creation date of August 7, 2024.
What is the intended impact of the mechanistic knowledge generated?
The intent is that improved mechanistic understanding will help move the field toward strategies that prevent, mitigate, or relieve HIV-associated complications that intersect with NIDDK-relevant disease areas such as diabetes, digestive diseases, kidney disease, and related metabolic or physiological disorders.
How closely must a project align with NIDDK mission areas?
Projects are expected to focus on organs, tissues, and biological systems within NIDDK mission areas and directly address how HIV contributes to related health problems in those systems.
What are some examples of organ systems and pathways highlighted as relevant?
The opportunity highlights metabolism, endocrine function, digestive diseases, liver and gastrointestinal biology, nutrition-related pathways, and kidney/urologic systems as examples of NIDDK-relevant focus areas.
What is the key theme applicants should keep in mind when shaping aims?
The central theme is mechanistic interrogation of HIV pathogenesis as it affects NIDDK-relevant tissues and systems, using a multidisciplinary team approach designed to deliver integrated, actionable biological insight.
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